Ubuhlalu bamabuyizi obukhulu busetshenziselwa ukuxilongwa komzimba, ukuxilonga amamolekyuli, ukuhlanzwa kwamaprotheni, ukuhlunga kwamaseli, nezinye izinkambu
I-Immunodiagnosis: Ubuhlalu be-immunomagnetic bakhiwa izinhlayiyana kazibuthe nezinto zokwakha ezinamaqembu asebenzayo. Ama-Protein Ligands (ama-antigodies noma ama-antibodies) ahlanganiswe namaqembu asebenzayo ubuhlalu kazibuthe, bese kuthi i-immunoassay yenziwa kusetshenziswa izakhiwo zamaprotheni kazibuthe.
Ukuxilongwa kwama-molecular (ukukhishwa kwe-nucleic acid): Ama-Nanoscale Agcucy ubuhlalu anamaqembu angaphezulu angahlukaniswa futhi adlwed yi-pompletic nucleic acid.
Ukuhlanjululwa kwamaphrotheni: I-Agarose exhumene ne-agarose ihlanganiswe ne-recombivelivence Protein a / g ngaphezulu kobuhlalu bakazi, amaprotheni athile abophayo e-proteina / g, ekugcineni afakwa ukuze athole ama-antibodies ahlanzekile.
Ukuthola Ukuxilongwa Ukuxilonga nokuthola ama-molecular:
Enye yezicelo ezibalulekile zobuhlalu bakaMagnetic butholakala ekuxilongeni emzimbeni, lapho sebephenduke amathuluzi asemqoka ekutholweni okunembile kwesifo. Isimo esiyingqayizivele sobuhlalu bakaMagnetic sivela emandleni abo okubamba nokuhlukanisa ama-antigen athile noma ama-antibodies avela kumasampula eziguli, enza lula inqubo yokuxilonga. Ngokuhlangana kwamaprotheni amaprotheni, njengama-antibodies noma ama-antibodies, kumaqembu asebenza ngobuhlalu basolwandle, abacwaningi bangenza ama-immunoasars ngempumelelo nangokunemba okuthuthukisiwe.Ukuxilongwa kwama-molecular, enye insimu ekhangayo, izinzuzo ezinkulu kakhulu ekusebenziseni ubuhlalu bamandla. Ngamasu wokuxilonga ama-molecular athola ukuvelela eminyakeni yamuva, ubuhlalu bakazi bamabutho bakazidlama iqhaza elibalulekile ekuhlukaniseni kanye nokukhipha ama-nucleic acid, njenge-DNA noma i-RNA, kusuka kumasampula e-biological. Lezi ubuhlalu zisebenza njengezixhaso eziqinile, lula ukuthwebula kahle nokuhlanzwa kwama-molecule aqondiwe. Le ndlela ethuthukile inike amandla ososayensi ukuba bazuze ukuxilongwa okunembile nangokwethembekile, okuholela emiphumeleni yeziguli engcono.
Ukuhlanzwa kwamaphrotheni kanye nokuhlunga kweseli:
Ubuhlalu bamandla bamabalantshi futhi bathola ukusetshenziswa okubanzi ekuhlanjweni kwamaprotheni, inqubo ebucayi ekuthuthukisweni kwezidakamizwa kanye nocwaningo lwe-biochemistry. Ngokuhlanganisa ama-ligands athile kubuhlalu, abacwaningi bangakwazi ukubopha futhi bakhiphe amaprotheni okuhlosiwe ngokuncipha okuphezulu kanye nezithelo. Le ndlela yokuhlanza isheshisa kakhulu inqubo yocwaningo ephelele, okuvumela ososayensi ukuthi bahlaziye futhi bafunde amaprotheni ngendlela enemininingwane eminingi.Ukuhlunga kweseli, ingxenye ebalulekile yezicelo ezahlukahlukene zezokwelapha nezocwaningo, kanti enye insimu izuze kakhulu ubuhlalu bamandla. Lokhu ubuhlalu, kuhlanganiswe ngama-biomaskers noma ama-antibodies, kusiza ukwahlukaniswa kanye nokuhlukaniswa kwabantu abahlukahlukene be-cell. Ngokusebenzisa amandla kazibuthe, ososayensi bangakwazi ukuhlunga kahle futhi bahlukanise amaseli asuselwa ezimfanelweni zabo ezingokomzimba nezisebenzayo. Ukukhululeka nokunemba kwale ndlela kuqinisile imizamo yocwaningo ekuqondeni izinqubo eziyinkimbinkimbi zamaselula, njengokuthuthuka komdlavuza kanye nokuphendula komzimba.
Isikhathi sePosi: Jun-25-2023